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ea0070aep1022 | Hot topics (including COVID-19) | ECE2020

miRNAs regulating BDNF and BDNFas in adipose tissue: Potential link between obesity and mood disorders

Lhamyani Said , Clemente Mercedes , Gentile Adriana , Chacón Pedro , Javier Pavón Francisco , José Tinahones Francisco , Olveira Gabriel , El Bekay Rajaa

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

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ea0073ep52 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The association of depression with adipose tissue inflammation related to obesity

Lhamyani Said , Mariel Gentile Adriana , Maria Isabel Cabrera Gonzalez , Sanchez Marin Laura , Serrano Antonia , Francisco José Tinahones , Olveira Gabriel , El Bekay Rajaa

Background and aimMajor depressive disorder (MDD) is one of the common mental disorder that affect more than 350 million subjects. MDD has been reported to be associated with systemic inflammation and obesity. However, there are no data that relate adipose tissue (AT) inflammation to MDD. The analysis of inflammatory markers in AT could pave the way to clarify the potential association between MDD and obesity. For this reason, the aim of our study was to...

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Endocrine Abstracts

miRNAs regulating BDNF and BDNFas in adipose tissue: Potential link between obesity and mood disorders

The association of depression with adipose tissue inflammation related to obesity

BiosciAbstracts